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KMID : 0370019950090000023
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Chung-Ang Journal of Pharmacal Sciences
1995 Volume.9 No. 0 p.23 ~ p.33
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Effect of Cucurbitacin B on the Streptozotocin induced Hyperglycemia in Rats
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Abstract
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The effects of cucurbitacin B on rat with streptozotcin-induced hyperglycemia were investigated.
The serum total cholesterol was decreased by administration of cucurbitacin B as compared with control group(streptozotocin only) However, the serum glucose and serum triglyceride level were not decreased by administration of cucurbitacin B. And serum GPT activity was significantly decreased 5 times by the pretreatment of cucurbitacin B at dose of 0.1, 0.2 and 0.4㎎/㎏ and 3 times by the posttreatment of Cucurbitacin B at a dose of 0.4㎎/㎏ as compared with control group(p<0.05). The serum GOT activity was significantly decreased 5 times by the pretreatment of cucurbitacin B at a dose of 0.2㎎/㎏ (p<0.01), and 5 times by the pretreatment of Cucurbitacin B at dose of 0.4㎎/㎏ (p<0.05) as compared with control group.
The lipid peroxidation in liver of the stretozotocin-induced hyperglycemic rats were decreased 3 times by the posttreatment of cucurbitacin B at a dose of 0.1㎎/㎏, 0.2㎎/㎏ and 0.4㎎/㎏ as compared with control group(p<0.05).
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